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By David S Baldwin; Jon Birtwistle

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However, the authors suggested that when there is a prolonged grief reaction of more than 6 months, which meets the criteria for major or minor depressive disorders, then these should be diagnosed and treated as mood disorders. Several antidepressants have been studied in bereaved people. In a small-scale open trial, Pasternak and coworkers51 found nortriptyline to be effective in treating people with bereavement-related depression in late life. Zygmont and associates52 carried out an open-trial pilot study of paroxetine for symptoms of traumatic grief, compared with the effects of nortriptyline in an archival contrast group, from an ongoing separate study.

The half-life is not as important as the time taken to replace stores of MAO after irreversible blockade. 7 describes the side-effects typically seen with TCAs. 8). Moclobemide Stringent dietary restrictions are necessary in patients taking traditional MAOIs, as naturally occurring monoamines (such as tyramine in cheese) and sympathomimetics in cough and cold medicines can interact with MAOIs to produce a fatally catastrophic hypertension. MAOI efficacy MAOIs are often used in cases of severe depression, especially those associated with lethargy and poor motivation.

10. MAOI pharmacokinetics MAOIs are characterized by rapid absorption, but toxic levels can occur in the slow acetylators. The half-life is not as important as the time taken to replace stores of MAO after irreversible blockade. 7 describes the side-effects typically seen with TCAs. 8). Moclobemide Stringent dietary restrictions are necessary in patients taking traditional MAOIs, as naturally occurring monoamines (such as tyramine in cheese) and sympathomimetics in cough and cold medicines can interact with MAOIs to produce a fatally catastrophic hypertension.

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